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Acute Myeloid Leukemia: Aging and Epigenetics

31 Dec 2019

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological disorder mainly affecting people of older age. AML initiation is primarily attributed to mutations in crucial cellular regulators such as epigenetic factors, transcription factors, and signaling genes. AML's aggressiveness and responsiveness to treatment depends on the specific cell type where leukemia first arose. Aged hematopoietic cells are often...

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PMID: 31906064
DOI: 10.3390/cancers12010103

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