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Article

An old leukaemia in young patients-Genetic characteristics of paediatric chronic myeloid leukaemia.

British journal of haematology - 1 Nov 2025

Metzler Markus, Branford Susan, Hijiya Nobuko, Sakamoto Kathleen

Abstract excerpt

Chronic myeloid leukaemia (CML) accounts for 2% of leukaemias in children and 9% in adolescents. While the BCR::ABL1 fusion gene remains a hallmark across all age groups, emerging evidence suggests that paediatric CML exhibits unique biological and clinical characteristics compared to its adult counterpart. Children often present with more aggressive clinical features and show distinct treatment response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40921705
DOI: 10.1111/bjh.70134
PMCID: PMC13502535

Genes

ABL1
BCR
ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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