Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

3 Dec 2018

Abstract excerpt

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation through various mechanisms including hepatitis B virus (HBV) and adeno-associated virus type 2 (AAV2) insertions, enhancer hijacking and recurrent CCNA2 fusions. Cyclin A2 or E1 alterations define a homogenous entity of aggressive HCC,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30531861
DOI: 10.1038/s41467-018-07552-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stressPMID 30531861Read ↗

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architectureSemantic proximity Read ↗

Diverse modes of genomic alteration in hepatocellular carcinoma.Semantic proximity Read ↗

High-resolution characterization of a hepatocellular carcinoma genome.Semantic proximity Read ↗

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architectureSemantic proximity Read ↗

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic InstabilitySemantic proximity Read ↗

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.Semantic proximity Read ↗

HBV integrations reshaping genomic structures promote hepatocellular carcinomaSemantic proximity Read ↗

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.Semantic proximity Read ↗

DNA replication stress stratifies prognosis and enables exploitable therapeutic vulnerabilities of HBV-associated hepatocellular carcinoma: an <i>in silico</i> strategy towards precision oncologySemantic proximity Read ↗

Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon Hepatitis B virus genome insertionSemantic proximity Read ↗

CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar CarcinomaSemantic proximity Read ↗

Comparative Transcriptomic and Epigenomic Analysis Highlights Hepatitis B Virus Infection Impact on Hepatocellular Carcinoma DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.