Article

Comparative Transcriptomic and Epigenomic Analysis Highlights Hepatitis B Virus Infection Impact on Hepatocellular Carcinoma Development

2025-10-21

Abstract excerpt

<title>Abstract</title> <p>Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), yet the molecular events linking infection to malignant transformation remain incompletely defined. Here, we integrated transcriptomic (RNA-seq) and epigenomic (ChIP-seq for H3K27ac and H3K27me3) data across normal hepatocyte-derived cells (WT), HBV-infected cells, and HCC samples to quantify ge...

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Literature Corpus work: 188b169c-4196-558c-9a6d-dce977c0b956
DOI: 10.21203/rs.3.rs-7850229/v1

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