Article
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
Nature genetics - 6 May 2012
Guichard Cécile, Amaddeo Giuliana, Imbeaud Sandrine, Ladeiro Yannick, Pelletier Laura, Maad Ichrafe Ben, Calderaro Julien, Bioulac-Sage Paulette, Letexier Mélanie, Degos Françoise, Clément Bruno, Balabaud Charles, Chevet Eric, Laurent Alexis, Couchy Gabrielle, Letouzé Eric, Calvo Fabien, Zucman-Rossi Jessica
Abstract excerpt
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Here, we performed high-resolution copy-number analysis on 125 HCC tumors and whole-exome sequencing on 24 of these tumors. We identified 135 homozygous deletions and 994 somatic mutations of genes with predicted functional consequences. We found new recurrent alterations in four genes (ARID1A, RPS6KA3, NFE2L2 and IRF2) not previously...
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