Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.

Brain : a journal of neurology - 1 Aug 2011

Engmann Olivia, Hortobágyi Tibor, Pidsley Ruth, Troakes Claire, Bernstein Hans-Gert, Kreutz Michael R, Mill Jonathan, Nikolic Margareta, Giese Karl Peter

Abstract excerpt

Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The functions of cyclin-dependent kinase 5 signalling in cognition and cognitive disorders remains unclear. Here, we show that in schizophrenia, a disorder associated with impaired cognition, p35 expression is reduced in relevant brain regions. Additionally, the expression of septin 7 and OPA1, proteins downstream of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Endophenotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inhibition, Psychological

Share to Interpersonal Relations

Share to Mucoproteins

Share to Postmortem Changes

Share to Reward

Share to Septins

Source

Open in PubMed Open full text

Identifiers

PMID: 21772061
DOI: 10.1093/brain/awr155
PMCID: PMC3155706

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.PMID 21772061Read ↗

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.Semantic proximity Read ↗

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.Semantic proximity Read ↗

Analysis Of Molecular Networks In The Cerebellum In Chronic Schizophrenia: Modulation By Early Postnatal Life Stressors In Murine ModelsSemantic proximity Read ↗

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.Semantic proximity Read ↗

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.Semantic proximity Read ↗

Sex-Specific Proteomics Changes Induced by Genetic Deletion of the Fibroblast Growth Factor 14 (FGF14) Regulator of Neuronal Ion ChannelsSemantic proximity Read ↗

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic ResponsesSemantic proximity Read ↗

Broader phenotypic traits and widespread brain hypometabolism in spinocerebellar ataxia 27.Semantic proximity Read ↗

MAP2 is Differentially Phosphorylated in Schizophrenia, Altering its FunctionSemantic proximity Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

PET neuroimaging reveals histone deacetylase dysregulation in schizophreniaSemantic proximity Read ↗

Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.