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Article

Therapeutic Potential of Isoform Selective Hdac Inhibitors for the Treatment of Schizophrenia

1 Sept 2013

Abstract excerpt

Increasing evidence supports a role for epigenetic involvement in some of the neurobiological alterations observed in neurodegenerative and psychiatric disorders including schizophrenia. In particular, there is mounting evidence implicating dysfunction in acetylation status, a chromatin modification mediated in part by HDACs, as a possible contributing factor to certain facets of this debilitating disease....

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PMID: 24024943
DOI: 10.4155/fmc.13.141

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