Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

28 Nov 2016

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Postmortem brain studies support dysregulated expression of the histone deacetylase enzymes, HDAC1 and HDAC2, as a central feature in diseases including schizophrenia, bipolar disorder, and depression. Our objective was to investigate HDAC expression in a large postmortem sample set representing healthy and disease brains. We used >700 well-characterized samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Phosphodiesterase function and regulation
Share to Schizophrenia research and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27959513
DOI: 10.1021/acschemneuro.6b00372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with SchizophreniaPMID 27959513Read ↗

PET neuroimaging reveals histone deacetylase dysregulation in schizophreniaSemantic proximity Read ↗

Single-nuclei transcriptomics of schizophrenia prefrontal cortex primarily implicates neuronal subtypesSemantic proximity Read ↗

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophreniaSemantic proximity Read ↗

Post-mortem molecular profiling of three psychiatric disordersSemantic proximity Read ↗

The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studiesSemantic proximity Read ↗

HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative DiseaseSemantic proximity Read ↗

The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studiesSemantic proximity Read ↗

Post-mortem molecular profiling of three psychiatric disordersSemantic proximity Read ↗

A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human PrimatesSemantic proximity Read ↗

Transcriptome Sequencing Revealed Significant Alteration of Cortical Promoter Usage and Splicing in SchizophreniaSemantic proximity Read ↗

Chromatin Alterations Associated With Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects With SchizophreniaSemantic proximity Read ↗

Recent advances in postmortem pathology and neurochemistry in schizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.