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Article

Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.

The Journal of investigative dermatology - 1 Jun 2019

Lambert Sylviane, Hambro Caely A, Johnston Andrew, Stuart Philip E, Tsoi Lam C, Nair Rajan P, Elder James T

Abstract excerpt

Psoriasis lesions are rich in IL-17-producing T cells as well as neutrophils, which release webs of DNA-protein complexes known as neutrophil extracellular traps (NETs). Because we and others have observed increased NETosis in psoriatic lesions, we hypothesized that NETs contribute to increased T helper type 17 (Th17) cells in psoriasis. After stimulating peripheral blood mononuclear cells with anti-CD3/CD28...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30528823
DOI: 10.1016/j.jid.2018.11.021
PMCID: PMC7092801

Genes

CD28
TRAF3IP2
CD4
IL17A
RORC

Variants

rs33980500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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