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Profiling targetable immune checkpoints in osteosarcoma

11 Sept 2018

Abstract excerpt

Osteosarcomas are aggressive bone tumors for which therapeutic advances have not improved over several decades. Unlike most pediatric tumors, the osteosarcoma genome is remarkably unstable, characterized by numerous copy number alterations and chromosomal structural aberrations. In this study, we asked if the targetable immune checkpoints CD274 (PD-L1), PDCD1LG2 (PD-L2), CD276 (B7-H3) and IDO1 are impacted by...

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PMID: 30524885
DOI: 10.1080/2162402x.2018.1475873

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