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Analysis of a large osteosarcoma sequencing data set elucidates patterns of genomic alterations.

Cancer - 15 Jul 2026

Bousquet Hannah G, Kuang Zheng, Vega Lorena Lazo de la, Ceca Evelina, Schiantarelli Julia, Honecker Julius, Hiemenz Matthew C, Forrest Suzanne J, Janeway Katherine A

Abstract excerpt

BACKGROUND: Genomic complexity and small case numbers make statistically robust assessment of mutational patterns in osteosarcoma difficult. The authors analyzed a large cohort of targeted next-generation sequencing data from osteosarcoma cases from young patients submitted for clinical testing to Foundation Medicine. METHODS: The osteosarcoma cohort included 653 patients: 109 pediatric (males, <13 years old;...

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Bone Neoplasms
Child
Genomics
High-Throughput Nucleotide Sequencing
Osteosarcoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-myc

Tumor Suppressor Protein p53

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Open in PubMed Open full text

Identifiers

PMID: 42424099
DOI: 10.1002/cncr.70500
PMCID: PMC13348730

Genes

CCND3
MYC
CDK4
MDM2
RB1
TP53
AURKB
BCL2L2
CCNE1
CDKN2A
GID4
NCOR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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