Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue byTMEM106Bknockdown

Abstract excerpt

Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia and lead to lysosomal storage pathology in neurons. We here report that physiological levels of mutant CHMP2B causes reduced numbers and significantly impaired trafficking of endolysosomes within neuronal dendrites, accompanied by increased dendritic branching. Mechanistically, this is due to the stable incorporation of mutant...

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