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Article

The role of CHMP2B in frontotemporal dementia

20 Jan 2009

Abstract excerpt

Mutations in the CHMP2B (charged multivesicular body protein 2B) gene that lead to C-terminal truncations of the protein can cause frontotemporal dementia. CHMP2B is a member of ESCRT-III (endosomal sorting complex required for transport III), which is required for formation of the multivesicular body, a late endosomal structure that fuses with the lysosome to degrade endocytosed proteins. Overexpression of...

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PMID: 19143633
DOI: 10.1042/bst0370208

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