Article
Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Feb 2015
Chassefeyre Romain, Martínez-Hernández José, Bertaso Federica, Bouquier Nathalie, Blot Béatrice, Laporte Marine, Fraboulet Sandrine, Couté Yohann, Devoy Anny, Isaacs Adrian M, Pernet-Gallay Karin, Sadoul Rémy, Fagni Laurent, Goldberg Yves
Abstract excerpt
The charged multivesicular body proteins (Chmp1-7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helical polymers that change the curvature of cellular membrane domains. Mutations in human CHMP2B cause frontotemporal dementia, suggesting that this protein may normally control some neuron-specific process. Here, we examined the function, localization, and interactions...
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