Article
Multi-scalar data integration decoding risk genes for chronic kidney disease.
BMC nephrology - 18 Oct 2024
Ding Shiqi, Guo Jing, Chen Huimei, Petretto Enrico
Abstract excerpt
BACKGROUND: Chronic Kidney Disease (CKD) impacts over 10% of the global population, and recent advancements in high-throughput analytical technologies are uncovering the complex physiology underlying this condition. By integrating Genome-Wide Association Studies (GWAS), RNA sequencing (RNA-seq/RNA array), and single-cell RNA sequencing (scRNA-seq) data, our study aimed to explore the genes and cell types relevant...
Topics
- Humans
- Genome-Wide Association Study
- Renal Insufficiency, Chronic
- Polymorphism, Single Nucleotide
- Single-Cell Analysis
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- Transcriptome
- Glomerular Filtration Rate
- Sequence Analysis, RNA