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Article

ZEB2, a master regulator of the epithelial–mesenchymal transition, mediates trophoblast differentiation

20 Nov 2018

Abstract excerpt

STUDY QUESTION: Does the upregulation of the zinc finger E-box binding homeobox 2 (ZEB2) transcription factor in human trophoblast cells lead to alterations in gene expression consistent with an epithelial-mesenchymal transition (EMT) and a consequent increase in invasiveness? SUMMARY ANSWER: Overexpression of ZEB2 results in an epithelial-mesenchymal shift in gene expression accompanied by a substantial increase...

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Share to Gestational Trophoblastic Disease Studies
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PMID: 30462321
DOI: 10.1093/molehr/gay053

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