Article

Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation

2026-07-01

Abstract excerpt

The human placenta is built by trophoblast cells that fuse together, secrete hormones, and invade the uterus, and defects in these processes contribute to pregnancy disorders such as preeclampsia. Because cell-cell fusion and hormone secretion are inherently non-cell-autonomous processes, their regulators have remained inaccessible to conventional pooled CRISPR screens. Here, we developed an arrayed CRISPR screen...

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Literature Corpus work: 810a5a71-e336-542f-a3bc-f62649400f74
DOI: 10.64898/2026.06.29.734890

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