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Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression

4 May 2023

Abstract excerpt

BACKGROUND: Extravillous trophoblast (EVT) cell invasion is a tightly regulated process that requires for a normal pregnancy. The epithelial-mesenchymal transition (EMT) has been implicated in EVT cell invasion. Growth differentiation factor-8 (GDF-8), a member of the transforming growth factor-beta (TGF-β) superfamily, is expressed in the human placenta and promotes EVT cell invasion by upregulating the...

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PMID: 37143106
DOI: 10.1186/s12964-023-01107-2

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