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GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression

15 Jun 2022

Abstract excerpt

BACKGROUND: Growth differentiation factor-11 (GDF-11), also known as bone morphogenetic protein-11, belongs to the transforming growth factor-beta superfamily. GDF-11 was first identified as an important regulator during embryonic development. Increasing evidence has demonstrated that GDF-11 regulates the development of various organs and its aberrant expressions are associated with the risk of cardiovascular...

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PMID: 35705978
DOI: 10.1186/s12964-022-00899-z

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