Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells

12 Nov 2018

Abstract excerpt

BACKGROUND: TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although TNS2 can bind with Axl, the details of their interactions have not been elucidated. TNS2 is involved in IRS-1 signaling pathway. In this study, we confirmed the relationship between TNS2 expression and the expression of Axl, IRS-1, PDK1 and Glut4 in pancreatic cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Liver physiology and pathology
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30419905
DOI: 10.1186/s12929-018-0465-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cellsPMID 30419905Read ↗

Expression and function of the insulin receptor substrate proteins in cancerSemantic proximity Read ↗

Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2Semantic proximity Read ↗

Divergent Roles for IRS-1 and IRS-2 in Breast Cancer MetastasisSemantic proximity Read ↗

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma CellsSemantic proximity Read ↗

Oncogenic Transformation by the Signaling Adaptor Proteins Insulin Receptor Substrate (IRS)-1 and IRS-2Semantic proximity Read ↗

ATP5B promotes the metastasis and growth of gastric cancer by activating the FAK/AKT/MMP2 pathwaySemantic proximity Read ↗

Protein Kinase B/AKT and Focal Adhesion Kinase: Two Close Signaling Partners in CancerSemantic proximity Read ↗

PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.Semantic proximity Read ↗

Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motilitySemantic proximity Read ↗

p85β regulates autophagic degradation of AXL to activate oncogenic signalingSemantic proximity Read ↗

Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2.Semantic proximity Read ↗

Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.