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Article

PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.

Molecular and cellular endocrinology - 15 Oct 2009

Gupta Amit, Dey Chinmoy Sankar

Abstract excerpt

Our laboratory has established a novel role of focal adhesion kinase (FAK) in vitro and in vivo, as a positive regulator of insulin signaling pathway. In vitro studies reported tyrosine dephosphorylation of FAK under insulin resistance in C2C12 skeletal muscle cells. A decrease in FAK tyrosine phosphorylation was also observed in skeletal muscle of insulin resistant Sprague-Dawley rats fed on high-fat-diet....

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Share to Deoxyglucose
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19501627
DOI: 10.1016/j.mce.2009.05.018

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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