Article
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.
Molecular and cellular endocrinology - 15 Oct 2009
Gupta Amit, Dey Chinmoy Sankar
Abstract excerpt
Our laboratory has established a novel role of focal adhesion kinase (FAK) in vitro and in vivo, as a positive regulator of insulin signaling pathway. In vitro studies reported tyrosine dephosphorylation of FAK under insulin resistance in C2C12 skeletal muscle cells. A decrease in FAK tyrosine phosphorylation was also observed in skeletal muscle of insulin resistant Sprague-Dawley rats fed on high-fat-diet....
Topics
- Animals
- Cell Differentiation
- Cell Line
- Deoxyglucose
- Down-Regulation
- Enzyme Inhibitors
- Focal Adhesion Protein-Tyrosine Kinases
- Inositol Polyphosphate 5-Phosphatases
- Insulin
- Insulin Resistance
- Mice
- Muscle, Skeletal
- Mutation
- PTEN Phosphohydrolase
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
- Phosphoinositide-3 Kinase Inhibitors
- Phosphoric Monoester Hydrolases