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p85β regulates autophagic degradation of AXL to activate oncogenic signaling

8 May 2020

Abstract excerpt

PIK3R2 encodes the p85β regulatory subunit of phosphatidylinositol 3-kinase and is frequently amplified in cancers. The signaling mechanism and therapeutic implication of p85β are poorly understood. Here we report that p85β upregulates the protein level of the receptor tyrosine kinase AXL to induce oncogenic signaling in ovarian cancer. p85β activates p110 activity and AKT-independent PDK1/SGK3 signaling to...

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PMID: 32385243
DOI: 10.1038/s41467-020-16061-7

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