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Article

Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2.

Molecular and cellular biology - 15 Jul 2018

Mercado-Matos Jose, Janusis Jenny, Zhu Sha, Chen Samuel S, Shaw Leslie M

Abstract excerpt

Although the insulin receptor substrate (IRS) proteins IRS1 and IRS2 share considerable homology and activate common signaling pathways, their contributions to breast cancer are distinct. IRS1 has been implicated in the proliferation and survival of breast tumor cells. In contrast, IRS2 facilitates glycolysis, invasion, and metastasis. To determine the mechanistic basis for IRS2-dependent functions, we...

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Source

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Identifiers

PMID: 29685905
DOI: 10.1128/MCB.00590-17
PMCID: PMC6024166

Genes

IRS2
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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