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Article

Divergent Roles for IRS-1 and IRS-2 in Breast Cancer Metastasis

15 Mar 2007

Abstract excerpt

The insulin receptor substrate (IRS) proteins are cytoplasmic docking proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in breast cancer. The IRS proteins do not contain intrinsic kinase activity but rather function by organizing signaling complexes to initiate intracellular signaling cascades. IRS-1 and IRS-2 are...

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PMID: 17361103
DOI: 10.4161/cc.6.6.3987

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