Aβ 42 /Aβ 40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease

Abstract excerpt

Missense mutations in presenilin 1 cause early onset familial Alzheimer's disease in a way that is not understood. Increased Aβ42/Aβ40 ratios are the most consistent biochemical phenotype of such mutations in cultured cells and in vivo, and are thus considered central to the amyloid hypothesis. Previously, an inverse relation has been observed between the Aβ42/Aβ40 ratio of such mutants and the clinical age of...

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