β‐Amyloid pathogenesis: Chemical properties versus cellular levels

Abstract excerpt

Although genetic Aβ variants cause early-onset Alzheimer's disease, literature reports on Aβ properties are heterogeneous, obscuring molecular mechanisms, as illustrated by recent failures of Aβ-level targeting trials. Thus, we combined available data on Aβ levels and ratios, aggregation propensities, toxicities, and patient data for Aβ variants and correlated these data to identify heterogeneity, significant...

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