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Article

Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.

Neuron - 20 Apr 2016

Xia Dan, Kelleher Raymond J, Shen Jie

Abstract excerpt

We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+ brains, though the Aβ42/Aβ40 ratio is slightly increased in KI/+ brains. Moreover, the FAD mutation impairs...

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Identifiers

PMID: 27100200
DOI: 10.1016/j.neuron.2016.03.009
PMCID: PMC4840410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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