Article
Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations.
Neuro-degenerative diseases - 1 Jan 2014
Tagami Shinji, Okochi Masayasu, Yanagida Kanta, Kodama Takashi, Arai Tetsuaki, Kuwano Ryozo, Ikeuchi Takeshi, Takeda Masatoshi
Abstract excerpt
BACKGROUND: Presenilin 1 (PS1) mutations associated with familial Alzheimer disease (FAD) generally increase the amyloid-β 42 (Aβ42) to Aβ40 ratio secreted in cultured cells. Some of these mutants reduce the secretion of Aβ40 rather than increase that of Aβ42. Since it has been difficult to estimate Aβ42 secretion in brains of PS1-FAD patients due to substantial Aβ42 accumulation, it remains unknown whether the...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Biomarkers
- Chromatography, Liquid
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Presenilin-1
- Tandem Mass Spectrometry