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Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer’s disease

2024-11-23

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> Changes to the relative abundance of amyloid-beta (Aβ) peptides are hallmarks of Alzheimer’s disease (AD). iPSC-derived neurons offer a physiological model of Aβ production. We employed unbiased, data-driven analyses to investigate combinations of Aβ peptides as AD biomarkers and the relative contribution of peptides to AD pathogenesis. <h4>METHODS</h4> We meas...

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Literature Corpus work
584336eb-3fd7-5435-ae78-7ec81df02d8b
DOI
10.1101/2024.11.23.624811
Open publication

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Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer’s diseaseDOI 10.1101/2024.11.23.624811
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