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Article

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

Neurobiology of aging - 1 Jun 2005

Duering Marco, Grimm Marcus O W, Grimm Heike S, Schröder Johannes, Hartmann Tobias

Abstract excerpt

More than 130 known mutations in the presenilin-1 (PS1) gene result in familial Alzheimer's disease (FAD) with a mutation specific age of disease onset. These mutations increase amyloid beta 42 (A beta42) levels, and this increase has been validated in recent years as one pathogenic factor in FAD. However, further malfunctions of mutant presenilin-1 are discussed as well. In order to assess the weight of A beta42...

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Identifiers

PMID: 15718035
DOI: 10.1016/j.neurobiolaging.2004.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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