Article
Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer's Disease.
Neurotoxicity research - 1 Dec 2020
Kabir Md Tanvir, Uddin Md Sahab, Setu Jinnat Ruksana, Ashraf Ghulam Md, Bin-Jumah May N, Abdel-Daim Mohamed M
Abstract excerpt
Alzheimer's disease (AD) is the most common cause of dementia. Mutations of presenilin (PSEN) genes that encode presenilin proteins have been found as the vital causal factors for early-onset familial AD (FAD). AD pathological features such as memory loss, synaptic dysfunction, and formation of plaques have been successfully mimicked in the transgenic mouse models that coexpress FAD-related presenilin and amyloid...
Topics
- Alzheimer Disease
- Animals
- Humans
- Mutation
- Presenilin-1
- Presenilin-2
- Proteolysis
- Signal Transduction