Article
The genetics of Alzheimer disease.
Cold Spring Harbor perspectives in medicine - 1 Oct 2012
Tanzi Rudolph E
Abstract excerpt
Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age. Twin and family studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the...
Topics
- ADAM Proteins
- ADAM10 Protein
- Age of Onset
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Apolipoproteins E
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Membrane Proteins
- Mutation