Article
The presenilin genes: a new gene family involved in Alzheimer disease pathology.
Human molecular genetics - 1 Jan 1996
Cruts M, Hendriks L, Van Broeckhoven C
Abstract excerpt
A positional cloning approach has led to the identification of two closely related genes, the presenilins (PS), for autosomal dominant presenile Alzheimer disease (AD): PS-1 at 14q24.3 and PS-2 at 1q31-q42. The PS-1 gene was identified by direct cDNA selection of yeast artificial chromosomes containing the candidate chromosomal region. Subsequently, the PS-2 gene was identified due to its high sequence homology...
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