Article
The presenilin genes: a new gene family involved in Alzheimer disease pathology.
Human molecular genetics - 1 Jan 1996
Cruts M, Hendriks L, Van Broeckhoven C
Abstract excerpt
A positional cloning approach has led to the identification of two closely related genes, the presenilins (PS), for autosomal dominant presenile Alzheimer disease (AD): PS-1 at 14q24.3 and PS-2 at 1q31-q42. The PS-1 gene was identified by direct cDNA selection of yeast artificial chromosomes cont...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Gene Expression
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Presenilin-1
- Presenilin-2
- Sequence Homology, Amino Acid