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Article

Antibacterial agents specifically inhibiting lipopolysaccharide synthesis.

Nature - 1 Jan 2000

Goldman R, Kohlbrenner W, Lartey P, Pernet A

Abstract excerpt

The spread of antibiotic resistance in Gram-negative bacteria has sustained a continuing search for new agents with antibacterial activity against this important class of bacterial pathogen. Because the biosynthesis of lipopolysaccharide (LPS) is unique to Gram-negative bacteria and required by them for growth and virulence, attempts have been made to discover or design antibacterial agents acting at this site;...

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PMID: 3041230
DOI: 10.1038/329162a0

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