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Article

Antibacterial activities and characterization of novel inhibitors of LpxC.

Antimicrobial agents and chemotherapy - 1 Jun 2002

Clements John M, Coignard Fanny, Johnson Ian, Chandler Stephen, Palan Shilpa, Waller Andrew, Wijkmans Jac, Hunter Michael G

Abstract excerpt

Lipid A is the hydrophobic anchor of lipopolysaccharide (LPS) and forms the major lipid component of the outer monolayer of the outer membrane of gram-negative bacteria. Lipid A is required for bacterial growth and virulence, and inhibition of its biosynthesis is lethal to bacteria. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a metalloenzyme that catalyzes the second step in the...

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Identifiers

PMID: 12019092
DOI: 10.1128/AAC.46.6.1793-1799.2002
PMCID: PMC127247

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