Article
Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2013
Richter Stefan G, Elli Derek, Kim Hwan Keun, Hendrickx Antoni P A, Sorg Joseph A, Schneewind Olaf, Missiakas Dominique
Abstract excerpt
The current epidemic of infections caused by antibiotic-resistant gram-positive bacteria requires the discovery of new drug targets and the development of new therapeutics. Lipoteichoic acid (LTA), a cell wall polymer of gram-positive bacteria, consists of 1,3-polyglycerol-phosphate linked to glycolipid. LTA synthase (LtaS) polymerizes polyglycerol-phosphate from phosphatidylglycerol, a reaction that is essential...
Topics
- Acyltransferases
- Animals
- Anti-Bacterial Agents
- Catalytic Domain
- Disease Models, Animal
- Drug Resistance, Microbial
- Enzyme Inhibitors
- Lipopolysaccharides
- Mice
- Microbial Sensitivity Tests
- Mutation
- Phosphatidylglycerols