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Article

Inhibition of lipopolysaccharide transport to the outer membrane in Pseudomonas aeruginosa by peptidomimetic antibiotics.

Chembiochem : a European journal of chemical biology - 13 Aug 2012

Werneburg Martina, Zerbe Katja, Juhas Mario, Bigler Laurent, Stalder Urs, Kaech Andres, Ziegler Urs, Obrecht Daniel, Eberl Leo, Robinson John A

Abstract excerpt

The asymmetric outer membrane (OM) of Gram-negative bacteria contains lipopolysaccharide (LPS) in the outer leaflet and phospholipid in the inner leaflet. During OM biogenesis, LPS is transported from the periplasm into the outer leaflet by a complex comprising the OM proteins LptD and LptE. Recently, a new family of macrocyclic peptidomimetic antibiotics that interact with LptD of the opportunistic human...

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PMID: 22807320
DOI: 10.1002/cbic.201200276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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