Article
Inhibition of lipopolysaccharide transport to the outer membrane in Pseudomonas aeruginosa by peptidomimetic antibiotics.
Chembiochem : a European journal of chemical biology - 13 Aug 2012
Werneburg Martina, Zerbe Katja, Juhas Mario, Bigler Laurent, Stalder Urs, Kaech Andres, Ziegler Urs, Obrecht Daniel, Eberl Leo, Robinson John A
Abstract excerpt
The asymmetric outer membrane (OM) of Gram-negative bacteria contains lipopolysaccharide (LPS) in the outer leaflet and phospholipid in the inner leaflet. During OM biogenesis, LPS is transported from the periplasm into the outer leaflet by a complex comprising the OM proteins LptD and LptE. Rece...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Biological Transport
- Carbon Radioisotopes
- Cell Membrane
- Escherichia coli
- Genetic Complementation Test
- Lipid A
- Lipopolysaccharides
- Microscopy, Electron
- Molecular Structure
- Mutation
- Peptidomimetics