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First and Stereoselective Synthesis of an α-(2→5)-Linked Disaccharide of 3-Deoxy-<scp>d</scp>-<i>manno</i>-oct-2-ulosonic Acid (Kdo)

12 Dec 2014

Abstract excerpt

Resistance of bacterial pathogens toward antibiotics has revived interest in lipopolysaccharide (LPS) motifs as potential therapeutic targets. The LPS of several pathogenic Acinetobacter strains comprises a 4,5-branched Kdo trisaccharide containing an uncommon (2→5)-linkage. In this contribution the first stereoselective glycosylation method for obtaining an α-Kdo-(2→5)-α-Kdo disaccharide in good yield is...

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PMID: 25496419
DOI: 10.1021/ol5033128

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