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Article

Foetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease.

Cardiovascular research - 1 Jul 2019

Huang Lei, Chen Xin, Dasgupta Chiranjib, Chen Wanqiu, Song Rui, Wang Charles, Zhang Lubo

Abstract excerpt

AIMS: Antenatal hypoxia negatively impacts foetal heart development, and increases the risk of heart disease later in life. The molecular mechanisms remain largely elusive. Here, we conducted a genome-wide analysis to study the impact of antenatal hypoxia on DNA methylome and transcriptome profiling in foetal and adult offspring hearts. METHODS AND RESULTS: Pregnant rats were treated with normoxia or hypoxia...

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Identifiers

PMID: 30395198
DOI: 10.1093/cvr/cvy277
PMCID: PMC6587923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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