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Article

Epigenetic Modulation in the Initiation and Progression of Pulmonary Hypertension

3 Sept 2019

Abstract excerpt

Pulmonary hypertension (PH) is a severe disease with multiple etiologies. In addition to genetics, recent studies have revealed the epigenetic modulation in the initiation and progression of PH. In this review, we summarize the epigenetic mechanisms in the pathogenesis of PH, specifically, DNA methylation, histone modifications, and microRNAs. We further emphasize the diagnostic and therapeutic potential of these...

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PMID: 31476913
DOI: 10.1161/hypertensionaha.119.13458

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