Article
Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.
Cardiovascular research - 1 Oct 2016
Grunert Marcel, Dorn Cornelia, Cui Huanhuan, Dunkel Ilona, Schulz Kerstin, Schoenhals Sophia, Sun Wei, Berger Felix, Chen Wei, Sperling Silke R
Abstract excerpt
AIMS: For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and their clinical course during life. Candidate approaches implied that DNA methylation might have...
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