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Article

Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.

Journal of molecular and cellular cardiology - 1 Feb 2016

Xiong Fuxia, Lin Thant, Song Minwoo, Ma Qingyi, Martinez Shannalee R, Lv Juanxiu, MataGreenwood Eugenia, Xiao Daliao, Xu Zhice, Zhang Lubo

Abstract excerpt

Large studies in humans and animals have demonstrated a clear association of an adverse intrauterine environment with an increased risk of cardiovascular disease later in life. Yet mechanisms remain largely elusive. The present study tested the hypothesis that gestational hypoxia leads to promoter hypermethylation and epigenetic repression of the glucocorticoid receptor (GR) gene in the developing heart,...

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Identifiers

PMID: 26779948
DOI: 10.1016/j.yjmcc.2016.01.003
PMCID: PMC4764467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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