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Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease

2 Aug 2021

Abstract excerpt

Clinically, intrauterine hypoxia is the foremost cause of perinatal morbidity and developmental plasticity in the fetus and newborn infant. Under hypoxia, deviations occur in the lung cell epigenome. Epigenetic mechanisms (e.g., DNA methylation, histone modification, and miRNA expression) control phenotypic programming and are associated with physiological responses and the risk of developmental disorders, such...

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PMID: 34440150
DOI: 10.3390/biomedicines9080944

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