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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

7 Jan 2022

Abstract excerpt

Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only antibodies (VHHs or single domain antibody fragments) targeting Tau as immuno-modulators of its pathologic seeding. A VHH issued from the screen against Tau of a synthetic phage-display library of humanized VHHs was selected for its...

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Identifiers

PMID: 35007758
DOI: 10.1016/j.ymthe.2022.01.009

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