Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation

17 Sept 2022

Abstract excerpt

INTRODUCTION: Neurofibrillary tangle (NFT) of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD) and related tauopathies. Tau lesion starts in the trans-entorhinal cortex, from where it spreads to limbic regions, followed by neocortical areas. The regional distribution of NFTs associates with the progression of AD. Accumulating evidence suggests that proteopathic tau can seed tau aggregation in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Ginkgo biloba and Cashew Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36114722
DOI: 10.1111/cns.13970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregationPMID 36114722Read ↗

Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tauSemantic proximity Read ↗

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s diseaseSemantic proximity Read ↗

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In VivoSemantic proximity Read ↗

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.Semantic proximity Read ↗

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo.Semantic proximity Read ↗

Tau seeding without tauopathySemantic proximity Read ↗

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy ModelsSemantic proximity Read ↗

<i>O</i> -GlcNAcylation effect on Tau in modulating its seeding and cellular transmission in Alzheimer’s DiseaseSemantic proximity Read ↗

Tau Seeding Mouse Models with Patient Brain-Derived AggregatesSemantic proximity Read ↗

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragmentSemantic proximity Read ↗

Conformation Determines the Seeding Potencies of Native and Recombinant Tau AggregatesSemantic proximity Read ↗

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.