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Article

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins

22 Aug 2018

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific groups of neurons. Due to clinical, genetic and pathological overlap, both diseases are considered as the extremes of one disease spectrum and in a number of ALS and FTD patients, fused in sarcoma (FUS) aggregates are present. Even in families with a monogenetic...

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PMID: 30379317
DOI: 10.1093/hmg/ddy303

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FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteinsPMID 30379317Read ↗

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