Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.

PloS one - 1 Jan 2012

Sasayama Hiroshi, Shimamura Mai, Tokuda Takahiko, Azuma Yumiko, Yoshida Tomokatsu, Mizuno Toshiki, Nakagawa Masanori, Fujikake Nobuhiro, Nagai Yoshitaka, Yamaguchi Masamitsu

Abstract excerpt

Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is an RNA-binding protein that is normally localized in the nucleus, but is mislocalized to the cytoplasm in ALS, and comprises cytoplasmic inclusions in ALS-affected areas. However, it is still unknown whether the neurodegeneration that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Antibody Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Motor Activity

Share to Motor Neurons

Share to Presynaptic Terminals

Share to Protein Interaction Domains and Motifs

Share to RNA-Binding Protein FUS

Source

Open in PubMed Open full text

Identifiers

PMID: 22724023
DOI: 10.1371/journal.pone.0039483
PMCID: PMC3378546

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.PMID 22724023Read ↗

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALSSemantic proximity Read ↗

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.Semantic proximity Read ↗

Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.Semantic proximity Read ↗

The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.Semantic proximity Read ↗

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Semantic proximity Read ↗

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.Semantic proximity Read ↗

Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.Semantic proximity Read ↗

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.Semantic proximity Read ↗

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashionSemantic proximity Read ↗

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Semantic proximity Read ↗

Highly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons.Semantic proximity Read ↗

Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.