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Article

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.

EMBO reports - 7 Jan 2021

Brunet Marie A, Jacques Jean-Francois, Nassari Sonya, Tyzack Giulia E, McGoldrick Philip, Zinman Lorne, Jean Steve, Robertson Janice, Patani Rickie, Roucou Xavier

Abstract excerpt

Novel functional coding sequences (altORFs) are camouflaged within annotated ones (CDS) in a different reading frame. We show here that an altORF is nested in the FUS CDS, encoding a conserved 170 amino acid protein, altFUS. AltFUS is endogenously expressed in human tissues, notably in the motor cortex and motor neurons. Over-expression of wild-type FUS and/or amyotrophic lateral sclerosis-linked FUS mutants is...

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Identifiers

PMID: 33226175
DOI: 10.15252/embr.202050640
PMCID: PMC7788448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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