Article
Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.
Protein & cell - 1 Jun 2011
Chen Yanbo, Yang Mengxue, Deng Jianwen, Chen Xiaoping, Ye Ye, Zhu Li, Liu Jianghong, Ye Haihong, Shen Yan, Li Yan, Rao Elizabeth J, Fushimi Kazuo, Zhou Xiaohong, Bigio Eileen H, Mesulam Marsel, Xu Qi, Wu Jane Y
Abstract excerpt
Mutations in the Fused in sarcoma/Translated in liposarcoma gene (FUS/TLS, FUS) have been identified among patients with amyotrophic lateral sclerosis (ALS). FUS protein aggregation is a major pathological hallmark of FUS proteinopathy, a group of neurodegenerative diseases characterized by FUS-immunoreactive inclusion bodies. We prepared transgenic Drosophila expressing either the wild type (Wt) or ALS-mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.