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Article

Animal Models of FUS-Proteinopathy: A Systematic Review.

Biochemistry. Biokhimiia - 1 Jan 2024

Rezvykh Alexander, Shteinberg Daniil, Bronovitsky Evgeny, Ustyugov Aleksey, Funikov Sergei

Abstract excerpt

Mutations that disrupt the function of the DNA/RNA-binding protein FUS could cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. One of the key features in ALS pathogenesis is the formation of insoluble protein aggregates containing aberrant isoforms of the FUS protein in the cytoplasm of upper and lower motor neurons. Reproduction of human pathology in animal models is the main tool...

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Identifiers

PMID: 38621743
DOI: 10.1134/S0006297924140037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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